https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45298 6 million deaths globally at the time of writing. COVID-19, instigated by the SARS - coronavirus-2 (SARS-CoV-2), causes unprecedented challenges in all facets of our lives, and never before brought scientists of all fields together to focus on this singular topic. While for the past 50 years research have been heavily focused on viruses themselves, we now understand that the host immune responses are just as important in determining the pathogenesis and outcomes of infection. Research in innate immune mechanisms is crucial in understanding all aspects of host antiviral programmes and the mechanisms underpinning virus-host interactions, which can be translated to the development of effective therapeutic avenues. This review summarizes what is known and what remains to be explored in the innate immune responses to influenza viruses and SARS-CoVs, and virus-host interactions in driving disease pathogenesis. This hopefully will encourage discussions and research on the unanswered questions, new paradigms, and antiviral strategies against these emerging infectious pathogens before the next pandemic occurs.]]> Tue 23 May 2023 08:41:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21831 0.05) of hypothalamic–pituitary–adrenal axis stress hormones, plasma interleukin-6, the magnitude of leukocytosis and neutrophilia and changes in neutrophil function. Conclusion: Acute DC consumption may affect insulin, glucose, antioxidant status and oxidative stress responses, but has minimal effects on immunoendocrine responses, to prolonged exercise.]]> Sat 24 Mar 2018 07:58:43 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26459 Sat 24 Mar 2018 07:27:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22111 Ifn-ε–deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-ε is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.]]> Sat 24 Mar 2018 07:13:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45072 Mon 29 Jan 2024 18:40:16 AEDT ]]>